产品货号：
Z34261
中文名称：
TERF2IP抗体
英文名称：
Anti-TERF2IP Antibody (Clone#1664CT564.52.88)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TERF2IP Antibody (Clone#1664CT564.52.88) |
| 指标别名 | DRIP5;hRap1;RAP1;RAP1 homolog;TERF2IP |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,FCM,IHC |
| 基因名称 | TERF2IP |
| 克隆号 | 1664CT564.52.88 |
| 抗体来源 | Mouse |
| 免疫原 | This TERF2IP antibody is generated from a mouse immunized with a recombinant protein from human TERF2IP. |
| 计算分子量 | 44kDa |
| 成分 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein G column,followed by dialysis against PBS |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Acts both as a regulator of telomere function and as a transcription regulator.Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome).In contrast to other components of the shelterin complex,it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair.Instead,it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR),which can affect telomere length.Does not bind DNA directly:recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2.Independently of its function in telomeres,also acts as a transcription regulator:recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors,and regulates gene expression.When cytoplasmic,associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65,leading to activate expression of NF-kappa-B target genes. |
| Uniprot ID | Q9NYB0 |
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